MAOA and persistent, pervasive childhood aggression

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The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression

Monoamine oxidase A (MAOA) genotypic variation has been associated with variation in aggression, especially in interaction with childhood trauma or other early adverse events. Male carriers of the low-expressing variant (MAOA-L) with childhood trauma or other early adverse events seem to be more aggressive, whereas female carriers with the high-expressing variant (MAOA-H) with childhood trauma ...

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Converging evidence emphasizes the role of an interaction between monoamine oxidase A (MAOA) genotype, environmental adversity, and sex in the pathophysiology of aggression. The present study aimed to clarify the impact of this interaction on neural activity in aggression-related brain systems. Functional magnetic resonance imaging was performed in 125 healthy adults from a high-risk community ...

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Background One emerging aspect of recent advances in neurocriminology is the discovery of possible links between violent criminal behaviour and genetics. Analysis of data from several studies indicates that the strongest link between genetic variation and aggression comes from monoamine oxidase A (MAOA); a gene encoding an enzyme responsible for catabolising amine neurotransmitters such as dopa...

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ژورنال

عنوان ژورنال: Molecular Psychiatry

سال: 2004

ISSN: 1359-4184,1476-5578

DOI: 10.1038/sj.mp.4001492